Investigating the Mechanisms of Mutant SOD1-mediated Motor Neuron Degeneration

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (Cu II(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

CPW Soon, PS Donnelly, BJ Turner, LW Hung, PJ Crouch, NA Sherratt, JL Tan, NKH Lim, L Lam, L Bica, SC Lim, JL Hickey, J Morizzi, A Powell, DI Finkelstein, JG Culvenor, CL Masters, J Duce, AR White, KJ Barnham

2011-12-23

Amyotrophic lateral sclerosis (ALS) is a progressive paralyzing disease characterized by tissue oxidative damage and motor neuron ..

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

CPW Soon, PJ Crouch, BJ Turner, CA McLean, KM Laughton, JD Atkin, CL Masters, AR White, QX Li

2010-04-01

Amyotrophic lateral sclerosis (ALS) is an adult-onset fatal neurodegenerative disorder characterized by progressive deterioration ..

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

BJ Turner, S Ackerley, KE Davies, K Talbot

2010-03-01

Mutant superoxide dismutase 1 (SOD1) action within non-neuronal cells is implicated in damage to spinal motor neurons in a genetic..

Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model

BJ Turner, NJ Parkinson, KE Davies, K Talbot

2009-06-01

Mutations in the ubiquitously expressed survival motor neuron 1 (SMN1) and superoxide dismutase 1 (SOD1) genes are selectively let..

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

BJ Turner, K Talbot

2008-05-01

Gain-of-function mutations in the Cu,Zn-superoxide dismutase (SOD1) gene are implicated in progressive motor neuron death and para..